Plant Transcription Factor Database
Previous version: v3.0
Trifolium pratense
HD-ZIP Family
Species TF ID Description
Tp57577_TGAC_v2_mRNA2318HD-ZIP family protein
Tp57577_TGAC_v2_mRNA34400HD-ZIP family protein
Tp57577_TGAC_v2_mRNA4181HD-ZIP family protein
Tp57577_TGAC_v2_mRNA6453HD-ZIP family protein
Tp57577_TGAC_v2_mRNA6454HD-ZIP family protein
Tp57577_TGAC_v2_mRNA6455HD-ZIP family protein
Tp57577_TGAC_v2_mRNA10715HD-ZIP family protein
Tp57577_TGAC_v2_mRNA3802HD-ZIP family protein
Tp57577_TGAC_v2_mRNA12072HD-ZIP family protein
Tp57577_TGAC_v2_mRNA16534HD-ZIP family protein
Tp57577_TGAC_v2_mRNA18858HD-ZIP family protein
Tp57577_TGAC_v2_mRNA34267HD-ZIP family protein
Tp57577_TGAC_v2_mRNA39684HD-ZIP family protein
Tp57577_TGAC_v2_mRNA30083HD-ZIP family protein
Tp57577_TGAC_v2_mRNA35677HD-ZIP family protein
Tp57577_TGAC_v2_mRNA34777HD-ZIP family protein
Tp57577_TGAC_v2_mRNA16537HD-ZIP family protein
Tp57577_TGAC_v2_mRNA16538HD-ZIP family protein
Tp57577_TGAC_v2_mRNA7986HD-ZIP family protein
Tp57577_TGAC_v2_mRNA29832HD-ZIP family protein
Tp57577_TGAC_v2_mRNA5895HD-ZIP family protein
Tp57577_TGAC_v2_mRNA39620HD-ZIP family protein
Tp57577_TGAC_v2_mRNA31237HD-ZIP family protein
Tp57577_TGAC_v2_mRNA16446HD-ZIP family protein
Tp57577_TGAC_v2_mRNA13490HD-ZIP family protein
Tp57577_TGAC_v2_mRNA5571HD-ZIP family protein
Tp57577_TGAC_v2_mRNA32555HD-ZIP family protein
Tp57577_TGAC_v2_mRNA19483HD-ZIP family protein
Tp57577_TGAC_v2_mRNA33705HD-ZIP family protein
Tp57577_TGAC_v2_mRNA4322HD-ZIP family protein
Tp57577_TGAC_v2_mRNA4323HD-ZIP family protein
Tp57577_TGAC_v2_mRNA4324HD-ZIP family protein
Tp57577_TGAC_v2_mRNA4750HD-ZIP family protein
Tp57577_TGAC_v2_mRNA38406HD-ZIP family protein
Tp57577_TGAC_v2_mRNA1498HD-ZIP family protein
Tp57577_TGAC_v2_mRNA39106HD-ZIP family protein
Tp57577_TGAC_v2_mRNA36204HD-ZIP family protein
Tp57577_TGAC_v2_mRNA38416HD-ZIP family protein
Tp57577_TGAC_v2_mRNA27227HD-ZIP family protein
Tp57577_TGAC_v2_mRNA11117HD-ZIP family protein
Tp57577_TGAC_v2_mRNA18019HD-ZIP family protein
Tp57577_TGAC_v2_mRNA16082HD-ZIP family protein
Tp57577_TGAC_v2_mRNA8586HD-ZIP family protein
Tp57577_TGAC_v2_mRNA11991HD-ZIP family protein
Tp57577_TGAC_v2_mRNA27255HD-ZIP family protein
Tp57577_TGAC_v2_mRNA15597HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401